Chronic obstructive pulmonary disease upper airway microbiota alpha diversity is associated with exacerbation phenotype: a case-control observational study.

Inclusion of these additional factors in the Shannon diversity model showed that oral wash Shannon diversity alone narrowly missed significance ( p = 0.07), while phenotype alone and the interaction of oral wash diversity and phenotype were non-significant.

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Our analysis of taxa distribution across anatomic sites and phenotypes identified shifts in the most abundant taxa in FE sputum samples compared to IE sputum samples, although the increases in Haemophilus and Moraxella abundance in FE sputum did not reach statistical significance.

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