DNA methylation profiling allows for characterization of atrial and ventricular cardiac tissues and hiPSC-CMs.

Clin Epigenetics · 2019 · PMC6560887 · PMID 31186048

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highly significantno p-value reported

Additional Welch two - sample t test comparing the β -values from atrial and ventricular samples of the 16 candidate CpG loci confirmed highly significant DNA methylation differences (Additional file 8 : Figure S8) with a mean delta β -value of Δ β = 0.46.

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did not reach statistical significanceno p-value reported

Three CpG loci ( TRAPPC9 (cg12865888), MYLK (cg07621385) and LINC00982 (cg08732466))—hereinafter referred to as ‘tendency-loci’—showed similar AVM patterns in hiPSC-CMs when compared to cardiac tissue samples but did not reach statistical significance (Fig. 7 ).

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