Fibroblast growth factor homologous factor 2 (FGF-13) associates with Nav1.7 in DRG neurons and alters its current properties in an isoform-dependent manner.

Voltage-dependence of activation of Nav1.7 channels was significantly hyperpolarized by 7.4 mV after knockdown of both FHF2A and FHF2B using miRNA-2core; however, knocking down FHF2A alone hyperpolarized the midpoint of activation by 3.4 mV, which did not reach statistical significance (miRNA-scrambled: −16.9 ± 1.3 mV; miRNA-FHF2A: −20.3 ± 1.4 mV, p = 0.246; miRNA-FHF2core: −24.3 ± 1.3 mV, p = 0.00182) ( Table 1 , Fig. 7 C and D).

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