Differences in other factors did not reach statistical significance (Table 2 , Figs. 1 , 3 ). qRT-PCR levels and correlations with immunohistochemical expression In primary high grade tumors, we found a significant correlation between VEGF-D IRS and VEGF-D mRNA (correlation coefficient, r = 0.991, p = 0.004), VEGFR1 PP and VEGFR1 mRNA (r = 0.967, p = 0.014) and VEGFR3 SI and VEGFR3 mRNA (r = − 0.655, p = 0.04).
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Expression profiles of VEGF-A, VEGF-D and VEGFR1 are higher in distant metastases than in matched primary high grade epithelial ovarian cancer.
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