Notably, we observed a significant trend for synapses that had a lower RRP before the induction of plasticity to increase their RRP size and vice versa ( Fig 3F and 3G ), which reduced the width of the RRP distribution ( Fig 3F : coefficient of variation [CV] before the stimulation: 56.4 ± 4.5; CV after the stimulation: 44.5 ± 4.4, Wilcoxon matched pairs signed-rank test, p < 0.05) and effectively resulted in the normalization of RRP of synapses formed between the pre- and the postsynaptic neuron.
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Differential role of pre- and postsynaptic neurons in the activity-dependent control of synaptic strengths across dendrites.
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