Randomized, double-blinded, placebo-controlled trial evaluating simethicone pretreatment with bowel preparation during colonoscopy.

Adverse events (simethicone vs placebo) such as abdominal pain/ cramping (11.9% vs 14.3%), nausea (15.5% vs 23.8%), and vomiting (4.8% vs 7.1%) were more prevalent in placebo group, however this did not reach statistical significance.

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