The Effect of Genetic Variation on the Placental Transcriptome in Humans.

Although in the validation dataset the effect of ALPG c.-318 G > A on ALPG expression level did not reach statistical significance (FDR = 0.18), the placentas carrying the minor A-allele exhibited a trend for increased ALPG and decreased ALPP expression ( ALPP/ALPG ratio FDR = 1.2 × 10 -2 ; Supplementary Table S8 ).

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Among these, ZSCAN9 represented an interesting novel locus modulated by several linked genetic variants and their highly significant eQTL effect was confirmed in experimental validation ( Figure 3A , Table 3 , and Supplementary Table S6A ).

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