Expression of Rorc was also significantly depleted in CD8+ T cell genomic DNA from CD4‐Cre + Rorc flox/flox mice, although the difference between genotypes did not reach statistical significance ( P = 0.23), presumably due to variation ( Supplementary Figure 3 A [ http://onlinelibrary.wiley.com/doi/10.1002/art.40657/abstract ]).
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Microbiota-Dependent Involvement of Th17 Cells in Murine Models of Inflammatory Arthritis.
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Comparison of naive Cre + Rorc flox/flox and CD4‐Cre − Rorc flox/flox mice revealed a nonsignificant trend toward increased abundance of SFB in naive Cre + mice, which is consistent with the previously reported findings in CD4‐Cre + STAT3 flox/flox mice 47 .