Involvement of Hsp90 and cyclophilins in intoxication by AIP56, a metalloprotease toxin from Photobacterium damselae subsp. piscicida.

Furthermore, Rad and 17-DMAG act cumulatively, since when Rad was applied in combination with 17-DMAG, the inhibitory effect was stronger when compared to pre-treatment with Rad (p = 0.0034) or 17-DMAG alone (although in this case, the difference did not reach statistical significance; p = 0.1954), resulting in an almost complete inhibition of p65 cleavage (Fig. 1 ).

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