Use of levosimendan in acute and advanced heart failure: short review on available real-world data.

In terms of adverse effects, the levosimendan group needed dose reductions due to hypotension (systolic blood pressure <80 mmHg; levosimendan 15%, placebo 9%), but this distinction did not reach statistical significance. 48 The LAICA trial was also a multicenter, prospective, randomized, double-blind, placebo-controlled, parallel-group trial that assessed the efficacy and safety of long-term intermittent infusion of levosimendan.

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