Decreased RORC expression and downstream signaling in HTLV-1-associated adult T-cell lymphoma/leukemia uncovers an antiproliferative IL17 link: A potential target for immunotherapy?

Int J Cancer · 2019 · PMC6590643 · PMID 30303535

Europe PMC DOI

hedged sentences

0.0000

closest p · 0.0× alpha

0.1000

boldest claim

The sentences

highly significantp < 10 −16actually significant

To validate the biological significance of this manually compiled pathway, we applied STRING protein–protein interaction enrichment analysis, which confirmed highly significant interaction for the RORC consensus pathway (expected number of edges: 11, observed number of edges: 83, enrichment p < 10 −16 ).

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did not reach statistical significancep = 0.10so close (0.05 < p ≤ 0.1)

We observed a similar tendency of decreased RORC expression with age in our Brazilian cohort ( r = −0.62), but this observation did not reach statistical significance levels ( p = 0.10), most probably due to the small size of this ATL cohort ( n = 8) (Fig. 2 b ).

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.