Association of stroke and bleed events in non-valvular atrial fibrillation patients with direct oral anticoagulant prescriptions in NHS England between 2013 and 2016.

PLoS One · 2019 · PMC6590892 · PMID 31233554

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Interestingly, AF patients above the age of 70 years observed approximately 40–50% reduction in stroke risk (both ischaemic and haemorrhagic) when prescribed a DOAC compared to warfarin, with the exception of AF patients above 90 years of age who showed a trend for an increased risk of haemorrhagic strokes when prescribed a DOAC ( Fig 2C ).

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