Clonality of CD4⁺ Blood T Cells Predicts Longer Survival With CTLA4 or PD-1 Checkpoint Inhibition in Advanced Melanoma.

Patients who survived longer than 48 months with PD-1 blockade tended to have greater numbers of distinct peaks in CD4 + T blood T cells than short-term survivors with anti-CTLA4 treatment, though the difference did not reach statistical significance ( Figure 6A , p = 0.098).

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