SOCS2 is part of a highly prognostic 4-gene signature in AML and promotes disease aggressiveness.

Sci Rep · 2019 · PMC6591510 · PMID 31235852

Europe PMC DOI

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closest p · 0.0× alpha

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boldest claim

The sentences

highly significantp = 1.2 * 10 −05actually significant

The 4-GES again predicted OS in a highly significant manner (adjusted p = 1.2 * 10 −05 and adjusted p = 5.6 * 10 −05 for cohorts 1 and 2, respectively; Fig. 2A,B ).

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did not reach statistical significanceno p-value reported

Among the ELN favourable patients, the difference did not reach statistical significance after adjustment for multiple testing.

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fell short of significanceno p-value reported

The resulting signature, 4-GES (consisting of SOCS2 , IL2RA , NPDC1 , and PHGDH ) was confirmed as an independent prognostic parameter in five of six additional data sets, including some that contained cytogenetically heterogeneous patient groups and/or employed different gene expression profiling technologies, and just fell short of significance in the sixth data set.

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