Ticagrelor induces paraoxonase-1 (PON1) and better protects hypercholesterolemic mice against atherosclerosis compared to clopidogrel.

PLoS One · 2019 · PMC6594647 · PMID 31242230

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0.0900

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showed a trendP = 0.090so close (0.05 < p ≤ 0.1)

Expression of phosphorylated inositol-requiring enzyme 1 (P-IRE1), a marker of endoplasmic reticulum stress, was significantly greater in the CLO group than the TIC group (P = 0.038); it also showed a trend toward greater expression in the CLO group than in the CTL group (P = 0.090), although there was no significant difference between the CTL and TIC groups (N = 7 for CLO; N = 6 for TIC and CTL, Fig 3F ).

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