Experimental evidence for the age dependence of tau protein spread in the brain.

Some old mice have ~3 times more Alz-50 immunoreactive neurons in the EC, although this did not reach statistical significance [ Fig. 2I ; young: (2.65 ± 1.4) × 10 −5 cells/μm 2 , n = 4; old: (4.97 ± 2.87) × 10 −5 cells/μm 2 , n = 5; P = 0.1857; Student’s t test].

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By Western blot, increased astrocytic glial fibrillary acidic protein (GFAP) was detected in two of three P301Ltau-expressing ECs, although this failed to reach significance (fig.

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