Early myopathy in Duchenne muscular dystrophy is associated with elevated mitochondrial H<sub>2</sub> O<sub>2</sub> emission during impaired oxidative phosphorylation.

J Cachexia Sarcopenia Muscle · 2019 · PMC6596403 · PMID 30938481

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showed a trendP = 0.11not close (p > 0.1)

Complex III (2.5 μM Antimycin A) and pyruvate dehydrogenase‐supported mH 2 O 2 (10 mM pyruvate, 0.5 μM Rotenone to inhibit Complex I) were decreased in the Quad (−53%, P = 0.05) and WG (−60%, P < 0.05), while the diaphragm showed a trend for increased Complex III mH 2 O 2 (+35%, P = 0.11) and no differences in pyruvate dehydrogenase‐supported mH 2 O 2 between D2. mdx and WT (Supporting Information, Figure S4A and S4B ).

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