Combined loss of GLP-1R and Y2R does not alter progression of high-fat diet-induced obesity or response to RYGB surgery in mice.

The metabolic chamber data obtained at room temperature were generally similar to the ones obtained at thermoneutrality, but some of the differences in energy expenditure and RER did not reach statistical significance ( Supplementary Figure S4 ). 3.2.4 Glycemic control parameters Intraperitoneal glucose tolerance measured at 3 weeks and insulin tolerance measured at 5 weeks after surgery were similarly affected by RYGB in both genotypes ( Figure 5 A,B).

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