At thermoneutrality, acute thyroxine-induced thermogenesis and pyrexia are independent of UCP1.

Ablation of the UCP1 gene did result in a somewhat reduced response to thyroxine treatment during the light phase, but the difference did not reach statistical significance during the night phase ( Figure 2 F). 3.2 Effect of chronic thyroxine treatment on body weight gain and food intake Since the thyroxine-treated mice demonstrated markedly elevated levels of metabolism, this would be expected to result in decreases in body weight and/or increases in food intake.

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