Glucose tolerance test showed a trend towards increased glucose levels in DMHGsKO mice at time points 40 min post-glucose administration and beyond, although the areas under the curve for DMHGsKO mice did not differ from those of controls ( Figure 3 G).
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G<sub>s</sub>α deficiency in the dorsomedial hypothalamus leads to obesity, hyperphagia, and reduced thermogenesis associated with impaired leptin signaling.
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