These data demonstrated an important trend among the majority of samples studied: while sporadic, differences (>±1 Da relative difference) 50 in deuterium uptake were observed across the length of the mAb, the majority of these changes were clustered within the Fab structural domains (V H , V L , C 1 , and C L ).
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The impact of standard accelerated stability conditions on antibody higher order structure as assessed by mass spectrometry.
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