Individual Vulnerability to Stress Is Associated With Increased Demand for Intravenous Heroin Self-administration in Rats.

Front Behav Neurosci · 2019 · PMC6603087 · PMID 31293400

Europe PMC DOI

hedged sentence

0.0890

closest p · 1.8× alpha

0.0890

boldest claim

The sentences

trending towards significancep = 0.089so close (0.05 < p ≤ 0.1)

In contrast with the previous reports (Banna et al., 2010 ), we show that yohimbine, a pharmacological stressor with high affinity for the α 2 -adrenergic receptor that induces noradrenergic tone, did not reinstate heroin seeking in rats with the previous history of stress although the grouped effect was trending towards significance ( p = 0.089).

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