Voluntary physical activity counteracts Chronic Heart Failure progression affecting both cardiac function and skeletal muscle in the transgenic Tgαq*44 mouse model.

As shown in panel B, a decrease in PGC‐1α protein content was found in Tg‐CTRL mice with respect to the age‐matched WT‐CTRL mice, in all phases of the disease (although at 14 months of age the difference did not reach statistical significance), suggesting that the basal level of mitochondrial biogenesis was impaired by CHF.

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