Methylome and transcriptome maps of human visceral and subcutaneous adipocytes reveal key epigenetic differences at developmental genes.

These “High DMRs” were found closer to the TSS of genes and had higher CpG density; there was a strong trend for increasing overlaps with CpG islands and shores with increasing ΔMe (χ 2 292.3 and 233.6 respectively, p < 22.e-16) with 4.5% and 27.8% of ≥0.3 DMRs overlapping CpG Islands or Shores respectively (Supplementary Fig.

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A marginally significant association of DMRs with body fat distribution SNPs was identified 21 , but none was seen with obesity SNPs 22 (Supplementary Information).

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