CDK1 and CDK2 regulate NICD1 turnover and the periodicity of the segmentation clock.

Once more, we could appreciate a clear trend for both Purvalanol B and RO‐3306‐treated embryos showing an increase in the last formed somite, which was not present in control DMSO embryos (Fig 7 G and H).

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Statistical analysis on the density of Western blot bands after immunoprecipitation confirmed an extremely significant reduction in the NICD‐FBXW7 interaction following Purvalanol B treatment (Fig 7 B).

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