Metformin induces lipogenic differentiation in myofibroblasts to reverse lung fibrosis.

Despite the variation in the response of fibroblasts isolated from different patients, the pattern of response was highly significant and clearly consistent among all samples (i.e., induction of lipogenic marker expression and suppression of COL1A1 expression).

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The results showed a trend for mild downregulation of the lipogenic markers PLIN2 (Fig. 5b ) and PPARg (Fig. 5c ) in parallel to a robust, significant downregulation of COL1A1 (Fig. 5d ).

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