Barely Significant
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Phase II trial of AKT inhibitor MK-2206 in patients with advanced breast cancer who have tumors with PIK3CA or AKT mutations, and/or PTEN loss/PTEN mutation.

Breast Cancer Res · 2019 · PMC6612080 · PMID 31277699

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While there was a trend of reduction in pAkt with treatment, this did not reach statistical significance and did not represent a significant change from controls.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.