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A Rationally Designed Humanized Antibody Selective for Amyloid Beta Oligomers in Alzheimer's Disease.

Sci Rep · 2019 · PMC6614461 · PMID 31285517

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showed a trendno p-value reported
Interestingly, APP/PS1 mice showed a trend (albeit not statistically significant) for greater CNS retention of huPMN310 over time compared to age-matched WT mice, consistent with engagement of target AβO present in the brain of transgenic mice but not WT littermates (Supplementary Fig. 10 ).

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