Interestingly, APP/PS1 mice showed a trend (albeit not statistically significant) for greater CNS retention of huPMN310 over time compared to age-matched WT mice, consistent with engagement of target AβO present in the brain of transgenic mice but not WT littermates (Supplementary Fig. 10 ).
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A Rationally Designed Humanized Antibody Selective for Amyloid Beta Oligomers in Alzheimer's Disease.
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