In Vitro Characterization of Hypoxia Preconditioned Serum (HPS)-Fibrin Hydrogels: Basis for an Injectable Biomimetic Tissue Regeneration Therapy.

In contrast to VEGF, the anti-angiogenic factor TSP-1 showed no significant variation with the length of the blood incubation period, despite a clear trend for early upregulation and later downregulation ( Figure 3 B), which has previously been suggested to be a hypoxia-driven phenomenon that promotes the switch towards an angiogenic phenotype [ 15 , 37 ].

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