Reactivating Immunity Primed by Acellular Pertussis Vaccines in the Absence of Circulating Antibodies: Enhanced Bacterial Control by TLR9 Rather Than TLR4 Agonist-Including Formulation.

In line with the respective Th2- and Th1-inducing properties of aP and wP vaccines ( 16 , 20 ), mTdap significantly induced IL-5-secreting splenocytes whereas DTwP preferentially induced IL-17- and IFNγ-producing cells, although differences in IFNγ did not reach statistical significance in this experimental setting ( Figure 1B ).

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