Targeting Mannitol Metabolism as an Alternative Antimicrobial Strategy Based on the Structure-Function Study of Mannitol-1-Phosphate Dehydrogenase in Staphylococcus aureus.

Unexpectedly, although the difference did not reach statistical significance, the administration of mannitol increased the death rate of mice infected with the WT strain from 30% to 50% ( Fig. 3C ), indicating that the presence of mannitol could also affect staphylococcal pathogenesis.

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