Lamin A molecular compression and sliding as mechanisms behind nucleoskeleton elasticity.

Measuring 300 dimers visualised by rotary metal shadowing EM revealed rod lengths ranging respectively from 40.7 to 56.9 nm and from 41.0 to 56.0 for 90% of measurements in Tris and NaPi buffer, with a significant trend towards shorter rods in NaPi buffer: median rod length of 51.1 nm in Tris buffer vs 49.2 nm in NaPi buffer ( p -value 4.45 × 10 −3 ) (Fig. 1b, c and Source Data file).

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