Closed testing using surrogate hypotheses with restricted alternatives.

Had the full cohort of 8290 subjects been employed, virtually every method of analysis would produce extremely significant differences.

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However, there is a barely non-significant (two-sided) benefit with ACEi for non-fatal stroke, and a barely significant benefit for congestive heart failure.

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Thus, H 0,1 would be rejected if the tests of H 0,1234 , H 0,123 , H 0,124 , H 0,134 , H 0,12 , H 0,13 , H 0,14 and H 0,1 were all nominally significant at level α .

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