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Canagliflozin, a sodium-glucose cotransporter 2 inhibitor, normalizes renal susceptibility to type 1 cardiorenal syndrome through reduction of renal oxidative stress in diabetic rats.

J Diabetes Investig · 2019 · PMC6626958 · PMID 30663266

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Expression levels of TLR2, TLR4, interleukin‐6, interleukin‐1β and chemokine (C‐C motif) ligand 3 were higher in OLETF than in LETO, although most of the differences did not reach statistical significance (Figure 3 ).

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