Deregulation of Hepatic Mek1/2⁻Erk1/2 Signaling Module in Iron Overload Conditions.

We detected that the activation of Mek1/2-Erk1/2, measured by phosphorylation status using immunoblot analysis, was on average 2-fold lower in the livers of Hfe -/- mice (with marginal significance of p = 0.0571), whereas the levels of pStat3 and pp90Rsk were not significantly changed ( Figure 4 ).

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This analysis revealed a decrease in the phosphorylation levels of Mek1 and p90 RSK in iron-loaded livers, and only marginally in case of Stat3 ( p < 0.0571); similarly, the levels of pErk1/2 showed a trend towards a decrease however the data were under the level of statistical significance ( Figure 1 ).

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