Relevance of In Vitro Metabolism Models to PET Radiotracer Development: Prediction of In Vivo Clearance in Rats from Microsomal Stability Data.

Pharmaceuticals (Basel) · 2019 · PMC6631687 · PMID 31013984

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a clear trendno p-value reported

While several authors demonstrated a clear trend towards underprediction with highly bound drugs [ 30 , 31 , 32 ], others reported a lack of correlation between free fraction and prediction bias [ 29 , 33 ] or mixed effects depending on the physicochemical characteristics of the drug (acidic, basic or neutral) [ 28 ].

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