Impact of uPA/PAI-1 and disseminated cytokeratin-positive cells in breast cancer.

Node-negative cases without chemotherapy In locally limited tumors without nodal involvement and without known administration of adjuvant chemotherapy, both proteases were highly significant prognostic factors for overall survival (uPA: positive vs negative 91 months (CI: 78–103 months) vs 119 months (CI: 108–129 months); P = 0.006 ( BH ST 0.017) (Fig. 3 a); (PAI-1: positive vs negative 94 months (CI: 84–103 months) vs 125 months (CI: 114–136 months); P = 0.004 BH ST 0.025 (Fig. 3 b).

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In our case series, we found a clear trend toward poor overall survival in PAI-1-positive cases when we analyzed the whole collective.

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