Pharmacological manipulation of DNA methylation normalizes maternal behavior, DNA methylation, and gene expression in dams with a history of maltreatment.

Sci Rep · 2019 · PMC6635500 · PMID 31311968

Europe PMC DOI

hedged sentences

0.0527

closest p · 1.1× alpha

0.0715

boldest claim

The sentences

marginally significantp = 0.0527so close (0.05 < p ≤ 0.1)

For DNMT1 , an ANOVA revealed a marginally significant main effect of infant condition ( F (1,61) = 3.903, p = 0.0527, Cohen’s d = 0.753), however, post-hoc analyses failed to meet significance (nurturing care versus maltreatment vehicle groups, p = 0.0852).

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marginal significancep < 0.06so close (0.05 < p ≤ 0.1)

Marginal significance was set at p < 0.06.

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did not reach statistical significancep = 0.0715so close (0.05 < p ≤ 0.1)

While numerically different levels of methylation were observed between control animals administered zebularine as compared to vehicle, this relationship did not reach statistical significance ( p = 0.0715).

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