mRNA expression of Aqp4 in the retina decreased specifically at 15 dpi (1.5-fold decrease) in EAE mice compared to healthy controls, however, this did not reach statistical significance after correction for multiple comparisons ( p = 0.04 uncorrected, p = 0.3 corrected; Fig. 8 c).
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Retinal pathology in experimental optic neuritis is characterized by retrograde degeneration and gliosis.
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