SOD1 is essential for oncogene-driven mammary tumor formation but dispensable for normal development and proliferation.

We found that primary breast cancers with elevated SOD1 levels are associated with highly significant lower relapse free survival ( Fig. 6a ), overall survival ( Fig. 6b ) and metastasis free survival ( Fig. 6c ).

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While in our model we observed a similar trend toward an elevation in hydrogen peroxide, it did not reach statistical significance.

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