Similar trends were also observed in the recurrence-free survival analyses of HCC patients, in which patients with downregulations of Pin1, RhoA or RhoC showed a trend of better prognosis for recurrence-free survival when compared with those with overexpressions, and those with co-overexpressions of Pin1+RhoA/RhoC demonstrated a significantly poor recurrence-free survival than those with no co-overexpressions.
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Overexpression of Pin1 and rho signaling partners correlates with metastatic behavior and poor recurrence-free survival of hepatocellular carcinoma patients.
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