Osteopontin counters human immunodeficiency virus type 1-induced impairment of neurite growth through mammalian target of rapamycin and beta-integrin signaling pathways.

Analyses of the activation of mTOR downstream target p70S6 kinase on Ser371 showed a trend that in HIV IIIB Env–treated cortical neurons, p70S6K was inhibited with increasing concentrations of OPN (Fig. 6 A).

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