CYP2D6-guided opioid therapy improves pain control in CYP2D6 intermediate and poor metabolizers: a pragmatic clinical trial.

Genet Med · 2019 · PMC6650382 · PMID 30670877

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approached significanceno p-value reported

Moreover, the benefit of CYP2D6-guided therapy in IM/PMs was large enough to result in a change in composite pain intensity ( P= 0.078) that approached significance in all participants prescribed tramadol or codeine at baseline.

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