HCV-specific CD4+ T cells of patients with acute and chronic HCV infection display high expression of TIGIT and other co-inhibitory molecules.

Sci Rep · 2019 · PMC6650447 · PMID 31337800

Europe PMC DOI

hedged sentences

0.0933

closest p · 1.9× alpha

0.0933

boldest claim

The sentences

did not reach statistical significancep = 0,0933so close (0.05 < p ≤ 0.1)

3D ), however this difference did not reach statistical significance (p = 0,0933) probably due to the small cohort size and larger cohorts are needed to investigate this question.

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a slight trendno p-value reported

During the acute HCV infection we found a slight trend of a reduction of the TIGIT/PD-1 frequency of HCV–specific CD4+ T cells of the patient group that developed a chronic HCV (n = 6) infection compared to patients who later spontaneously eliminated the virus (n = 4) (Fig. 3D ), however this difference did not reach statistical significance (p = 0,0933) probably due to the small cohort size and larger cohorts are needed to investigate this question.

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