Acute and Chronic Sleep Deprivation-Related Changes in N-methyl-D-aspartate Receptor-Nitric Oxide Signalling in the Rat Cerebral Cortex with Reference to Aging and Brain Lateralization.

In a similar way, assessments and cross-comparison of NOS isoforms in animals of different age groups with and without exposure to acute SD showed considerable age-dependent decrease but only in nNOS (the bilateral drops to 48.8% and 41.6%) and eNOS activity (the significant drop to 58.7% in the L side, that with borderline significance to 65.1% in the R side), with the activity levels of iNOS remaining stable across different age groups ( Figure 5 A–C).

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Nevertheless, the values of t-test did not reach statistical significance as compared to old controls.

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