A Review of the Hereditary Component of Triple Negative Breast Cancer: High- and Moderate-Penetrance Breast Cancer Genes, Low-Penetrance Loci, and the Role of Nontraditional Genetic Elements.

J Oncol · 2019 · PMC6652078 · PMID 31379942

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did not reach statistical significanceno p-value reported

In a meta-analysis of 4,754 ER- breast cancer cases and 31,663 controls from three GWAS, SNP rs2284378 on chromosome 20q11 was associated with ER- tumors (P=1.1x10 −8 ) and showed a stronger association with TNBC (OR=1.16, P=6.4x10 −3 ) than for ER-/HER2+ tumors (OR=1.07; P=0.41), although the differences did not reach statistical significance [ 60 ].

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