Integrative analysis of loss-of-function variants in clinical and genomic data reveals novel genes associated with cardiovascular traits.

At the same time, sample size issues could mask true associations trending towards significance (hence we used a less stringent cutoff p < 0.1).

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However, whereas weight loss following DGAT2 inhibition was borderline significant (Fig. 4 g), the lowering of fasting plasma glucose levels was more pronounced than in mice treated with the DGAT1 inhibitor (Fig. 4 h).

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