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Direct in situ labeling of target drugs with a fluorophore probe to improve MALDI-MS detection sensitivity in micro-liter plasma.

Sci Rep · 2019 · PMC6658545 · PMID 31346224

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a clear trendno p-value reported
For green methods, miniaturization is a clear trend in analytical chemistry motivated by the need to solve the limitations of conventional analytical systems and aimed at providing more efficient and environmentally friendly systems 58 , 59 .

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.