Synergy of therapeutic heterologous prime-boost hepatitis B vaccination with CpG-application to improve immune control of persistent HBV infection.

Sci Rep · 2019 · PMC6658704 · PMID 31346211

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did not reach statistical significanceno p-value reported

Consistent with an hepatic expansion of vaccine-induced T cells, we found more HBcAg-specific CD8 T cells in the livers but not spleens in AAV-HBV transduced mice after sequential application of heterologous prime-boost vaccination and CpG injection, although this did not reach statistical significance (Fig. 4c,d ).

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