21 In adolescents aged 10–16 years with type 1 diabetes and urine albumin-to-creatinine ratio values in the upper tertile, ACE inhibition was associated with a lower incidence of microalbuminuria, although this association did not reach statistical significance. 40 In a small group of normotensive adolescents with type 1 diabetes who had microalbuminuria or nephropathy, the ACE inhibitor captopril was associated with a significantly decreased albumin excretion rate. 47 The dose of pharmacological management should be titrated to ensure blood pressure is w
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